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In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]
Ricci G, Del Boccio G, Pennelli A, Aceto A, Whitehead EP, Federici G
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1994;22(7):S8S11
A series of 3-8 treatments spaced 4-6 weeks apart may be recommended for best results
Increased levels of TGF- have also been shown to reduce GCL and GSH synthesis
