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High levels of chemokines can lead to the activation of the trigeminal nerve (an essential structure in migraine), the release of vasoactive peptides, and other biochemical mediators like nitric oxide

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Another long-term follow-up study reported that VNS combined with tactile therapy improved perception in the left hand and arm after stroke and proposed the idea that VNS may enhance synaptic connections to the muscle tissue of the rehabilitated upper limb by facilitating remodeling of the cortical-spinal motor nerve circuit (Meyers et al., 2018)