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A cyclic form of GSH, which may occur under certain conditions, such as neutral to basic pH, exposes the SH moiety, making it more reactive

Nature 507 , 253257, doi: 10.1038/nature12970 (2014)

As a cellular model of tauopathy, we used human neuroblastoma SH-SY5Y cells stably overexpressing the P301L mutation (P301L cells) in the MAPT gene of chromosome 17 and tagged with a green fluorescent protein (GFP)

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Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines

Moving past a defensive posture and toward understanding pathophysiology requires careful focus on research methods