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Although chemopreventive effects were identified through epidemiological evidence, chemical carcinogenesis models and transgenic mouse models, more extensive mechanistic studies were performed to evaluate its therapeutic potential in various pre-clinical models

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Eumelanin makes skin dull and dark while pheomelanin increases the luminosity of the skin

Although these results only show the potential utility of domperidone for the treatment of WD in vitro, this study demonstrates the importance of functional characterization of mutants, even when a clear genotypephenotype correlation cannot be established
The Role of B-Vitamins B-vitamins, specifically B6, B9 (folate), and B12, are essential for the natural production of glutathione in the body
