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Despite its ability to induce cancer cell apoptosis, D did not show strong capacity to clear senescent cells when used as a monotherapy

47 In an open-label substudy of patients with type 2 diabetes and MASH (n = 502), tirzepatide resulted in a significant reduction in liver fat compared with insulin degludec after 52 weeks

A His 6 tag was introduced at the C-terminus of CopR for nickel affinity purification

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Strain construction The gsh2 mutants were constructed with deletion cassette prepared via three-step overlapping PCR using primers listed in Table S2 with WT genomic DNA and the pJAF15 plasmid as templates

Lack of reliable CSC biomarkers Identifying reliable CSC biomarkers remains a major challenge in CSC research and therapeutic targeting