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Betaine is a choline-derived metabolite and a methyl group donor with antioxidant, anti-inflammatory and osmoprotectant properties

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Using a knowledgebase-driven approach, we performed vote counting analyses to identify consistently upregulated or downregulated metabolites in the brain, blood, and urine in animal models of depression

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This study provides a foundational understanding of the relationship between a high-fat diet, gut microbiota, and hyperuricemia, and explores potential inflammatory targets

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Hydrophobic or charged surfaces bind to opsonins (e.g., immunoglobulins, complement factors), enhancing clearance, whereas PEGylated or zwitterionic surfaces bind dysopsonins (albumin, clusterin), extending circulation [93]

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doi: 10.1074/jbc.M500356200

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