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Fumarate, generated from arginine via argininosuccinate lyase, is electrophilic and can conjugate with GSH to form succinicGSH, directly depleting the intracellular antioxidant reserve and accelerating ferroptosis [106]

P., Holjevac J

doi: 10.1210/jc.2016-1473 16 MollerLDalmanLNorrelundHBillestrupNFrystykJMollerNet al

Pregnancy Pregnancy Category B: Reproduction studies have been performed in rats, mice and rabbits at doses up to 20 times the human dose, and have revealed no evidence of impaired fertility or harm to the fetus due to cyclobenzaprine HCl

International Wound Journal , 20(6), 2414-2423
