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The substratereceptor complex is internalized by endosomes via the clathrin-dependent pathway, followed by lysosomal hydrolysis, where the lipid is dissociated from the complex due to a low pH, and the receptor is recycled back to the cell surface [156,157]

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Kometani T, Yoshino I, Miura N, Okazaki H, Ohba T, Takenaka T, Shoji F, Yano T, Maehara Y (2009) Benzo[a]pyrene promotes proliferation of human lung cancer cells by accelerating the epidermal growth factor receptor signaling pathway

However, the biggest obstacle is the paucity of available analytical standards

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