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The authors of this Perspective summarize the knowledge on irAEs that has been obtained from different sources of big data.

Synonyms: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide

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Collectively, our results highlight the limitation of APR-246 as a p53-rescuing drug because of its overwhelming off-target effects on the redox system at doses that are sufficient to induce ferroptosis but insufficient to rescue mutant p53.

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