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Strategies to acquire high-level clinically-relevant resistance to antibiotics are exceedingly wide-ranging, and our understanding of this phenomenon at the molecular and population levels is now enabling us to understand the details and scope of this serious health threat

2018 Dec;100:105-117

Using flow technology, Buchwald, Pentelute, and colleagues engineered heme enzymes for enantiodivergent catalysis investigations 56

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The results showed that they inhibit the monophenolase (IC 50 = 1.01 to 18.4 M) and diphenolase (IC 50 = 5.22 to 84.1 M) actions of tyrosinase

10.1016/j.addr.2008.09.010 70 GriesenbachU.AltonE