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Cytochrome P450 1b1 expression regulates intracellular iron levels and oxidative stress in the retinal endothelium

Your body excels at making glutathione, but sometimes life gets in the way

Dual inhibition disrupts redox homeostasis, amplifies ROS, and lowers the IC50 to nanomolar levels, highlighting their potential for repurposing in glioblastoma therapy

Folinic acid (Leucovorin) is a derivative of folic acid, and is FDA approved to decrease the toxic effects of methotrexate on rapidly dividing host tissues that include bone marrow and GI mucosa

After GSH donates its electron, it becomes oxidized and leads to the formation of glutathione disulfide (GSSG)

Gullner et al