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Osburn, S
In the absence of MTAP, the substrate methyl thionyl adenosine (MTA) accumulates and acts as a selective inhibitor of PRMT5 to inhibit PRMT5 methylation activity, 237 whereas MAT2A can produce the PRMT5 substrate SAM, 238 allowing PRMT5 to exert its oncogenic effect
Fabricado en la UE
Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats
2015 doi: 10.1001/jamapsychiatry.2014.2502
