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Ipamorelin is popular because it stimulates GH release without significantly affecting cortisol or prolactin, unlike some other GHRPs

Second, synthetic lethal relationships identified in vitro do not always translate to animal models 63 , underscoring the need for an APC-deficient CRC model with dual GSTP1/PHD2 loss

For example, IGF-IR and ErbB3 were significantly upregulated in ovarian cancer cells resistant to the anti-ErbB2 mAb trastuzumab [116]

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Din OS, et al

Zinc dysregulation within the endolysosomal system also intersects with cancer biology: the alcohol-deterrent and emerging anticancer agent disulfiram disrupts endolysosomal structure and raises intraluminal zinc in breast cancer cells, implicating zinc dysregulation in its cytotoxicity and suggesting that extracellular zinc availability modulates its efficacy 169