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It aims to improve patients' functioning and quality of life by increasing psychological flexibility, defined as the ability to observe and accept aversive and disturbing thoughts, emotions and bodily sensations without reacting to them, and to promote behavior consistent with personal values [96]

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Indeed, the presence of cannabinoid receptors in intracellular organelles as mitochondria or lysosomes, or in nuclear targets as PPAR might impact energy consumption, metabolism and cell death

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