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Positron emission tomography studies revealed that lack of sleep also causes inefficient glucose utilization especially in higher-order brain regions such as prefrontal cortex, thalamus, hippocampus and cortex that ultimately lead to impairments in cognitive functions (Wu et al., 1991

Quizartinib versus salvage chemotherapy in relapsed or refractory FLT3-ITD acute myeloid leukaemia (QuANTUM-R): a multicentre, randomised, controlled, open-label, phase 3 trial

When the pathways that inhibit lipid peroxidation in a cell fail, the chain reaction eventually reaches cell membrane lipids, causing structural and functional damage and leading to ferroptosis [19]

These investigations not only provide a novel perspective for understanding HIRI but also establish a theoretical foundation for precise immunomodulatory interventions, potentially paving new avenues for future therapeutic strategies