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A study employing single-cell analysis of IRI kidneys has revealed that signals promoting ferroptosis, such as decreased expression of GPX4, play a role in fibrosis resulting from maladaptive repair of injured tubules, thereby contributing to the transition from AKI to CKD [32]

Retrieved from Collins, L

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Activated IRPs (IRP1 and IRP2) consequently bind with IREs of ferritin and SLC40A1 to inhibit their translations and stabilize expressions of TFR, therefore restoring labile iron homeostasis [32, 35, 36]

Food sources are one way to get NAC naturally, and some food sources rich in NAC are: Lean protein such as chicken and fish Eggs Nuts Legumes Food sources rich in sulfur are also good options if you are looking to boost your NAC levels