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In support of this observation, over expression of GS in a yeast model failed to increase GSH levels, whereas overexpression of GCL did [18]

Alisol A 24-acetate Ameliorates Nonalcoholic Steatohepatitis by Inhibiting Oxidative Stress and Stimulating Autophagy through the AMPK/mTOR Pathway

Plant J 113:13101329 Benschop JJ, Mohammed S, Flaherty M, Heck AJR, Slijper M, Menke FLH (2007) Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis

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This approach reduces the energetic demand of digestionwhich can itself be a trigger for PEMwhile ensuring a continuous supply of nutrients to the starving cells
