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The MTHFR gene produces an enzyme that helps regulate homocysteine levels in the body, and when this process is impaired due to a genetic variation, we can end up with higher levels of homocysteine
In most ferroptosis-related conditions including hepatic steatosis, cardiomyopathy, spinal cord injury, and BPA-induced liver damage, both enzymes are simultaneously upregulated, promoting lipid peroxidation and enhancing ferroptotic signaling (7073)
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2d and Extended Data Fig
