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[DOI] [PMC free article] [PubMed] [Google Scholar] Krenkel O., Mossanen J

Another drug repurposed is metformin (clinically used as an anti-diabetic) which is being used as an AMPK activator, currently in phase II clinical trials for CLL (ClinicalTrials.gov: NCT01750567) (105, 106)

Effects of raw red beetroot consumption on metabolic markers and cognitive function in type 2 diabetes patients

were the first to pioneer the field of rationally designed matrices, synthesizing derivatives of CHCA and DHB, which were used to tune the proton affinity and improve the ionization efficiency of the analytes