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In vitro and in vivo Down syndrome models revealed that supplementation of mice with low molecular weight antioxidants such as -tocopherol reduced the level of oxidative stress, attenuated degeneration of cholinergic neurons, and improved working memory (Lockrow et al
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doi: 10.1210/er.2002-0015 26 SchmidtKLKryger-BaggesenNByskovAGAndersenCY

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The three main human pathogens Bartonella species produces a protein that stimulates angiogenesis and probably facilitates the development of vascular lesions during infection