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nDNA mutations impact several processes, such as the formation of MRC subunits, assembly factors, intergenomic signaling, mitochondrial protein synthesis, lipid metabolism, mitochondrial dynamics (including fusion and fission), and coenzyme Q10 homeostasis (2)

Clinical trials have demonstrated that weekly dulaglutide administration provides glycemic control comparable to once-daily liraglutide, while offering improved adherence and patient convenience

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Alsaqati M, Heine VM, Harwood AJ

Protective role of cholesterol in A-induced toxicity As indicated above, cholesterol can protect cells from A-induced membrane perturbations and cytotoxic effects (Figure 2)