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Any perturbation of this balance, caused by excessive production of disulphide bonds during normal protein secretion or the production of mutant misfolded protein, might cause an excess of ROS to accumulate and ultimately lead to cell death

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ECM maturation facilitates cellular transformation, which results in embryogenic progression and organ development

(2005) Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells

GSH provides reducing equivalents to antioxidant enzymes, hydroxyl radicals, ROS and is itself oxidized to GSSG