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An integrated metabolomics workflow for the quantification of sulfur pathway intermediates employing thiol protection with N-ethyl maleimide and hydrophilic interaction liquid chromatography tandem mass spectrometry

This environment accelerates hemoglobin S polymerization , causing red blood cells to sickle, occlude medullary capillaries, and induce microinfarctions

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The complexity of metabolic networks demands multipronged strategies that combine metabolic modulators with immune checkpoint inhibitors (ICIs) or other conventional therapies

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