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The reduction in the rate of methylation also reduces the transfer of homocysteine into the sulphation cycle thereby resulting in lower production of Glutathione and increased production of pyroglutamate The primary reason for the chronic fatigue seen in CFS is the reduced production of creatine, the energy transfer molecule within the cytoplasm of the cell

doi: 10.1007/s11926-017-0628-x 305 BlauensteinerJBertinatRLenLERiedererMSeplvedaNWestermeierF

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The majority of events were reported as diabetic retinopathy (4%, 2.7%, and 2.7%, respectively) and non-proliferative retinopathy (0.7%, 0%, and 0%, respectively)