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This neuroprotective effect was proposed to be the result of an induction of anti-apoptotic factors such as activated kinase 1 (PAK1), protein kinase B (AKT), lim domain kinase 2 (LIMK2), mitogen-activated protein kinase, and cofilin

Monitor renal function regularly and adjust the dosage as necessary

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In primary human lymphocytes, folate deprivation decreased cell proliferation and increased apoptosis, cell cycle arrest, and DNA strand damage (165) ( Table 2 )

[DOI] [PMC free article] [PubMed] [Google Scholar] 174.Pacifici R., Marchei E., Salvatore F., Guandalini L., Busard F.P., Pichini S

Specifically, performance on digit span and various recall tasks did not differ between the 174 patients who were given 2,000 IU/day of synthetic -tocopherol (equivalent to 900 mg/day of RRR --tocopherol) and the 174 patients who were administered a placebo (121)