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Molkentin, J

Despite application of certain therapeutic interventions in clinical practice, such as antioxidants (vitamin E, vitamin C and N-acetylcysteine), anti-inflammatory (corticosteroids, non-steroidal anti-inflammatory drugs), Calcium Channel Blockers (verapamil, dantrolene) effective treatment for IRI remains challenging

The molecules unique structure enables it to bind and remove toxins through hepatic conjugation pathways, making it essential for detoxification

The aforementioned macamide also reversed testicular toxicity, and ethanolic extract decreased spermatogenic tubule vacuolization and testicular lesions, eventually recovering spermatogenic epithelium and inhibiting testicular stromal proliferation (Yu et al., 2020b)

[DOI] [PubMed] [Google Scholar] Rouhier N., Unno H., Bandyopadhay S., Masip L., Kim S.K., Hirazawa M., Gualberto J.M., Lattard V., Kusunoki M., Knaff D.B., Goergiou G., Hase T., Johnson M.K., Jacquot J.P