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The early progenitors within the adult SGZ and SVZ retain the capacity to specify multiple cell types and it is clear that TF networks determine fate specification and differentiation of newly born neurons

Since DNA replication stress can also be regulated by the redox status, we then measured ROS, GSSG, and reduced GSH in these cells

By contrast, our work stratifies patients into high and low glutathione metabolic cohorts according to the metabolic heterogeneity previously observed

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Of which, compounds 17 19 were strongly cytotoxic to the HeLa and HL-60 cells with IC 50 values ranging from 0.1 to 3.9 mol/L whilst 20 22 were inactive

It corresponds, in simplified terms, to the increase in the fraction of active ingredient actually available after ingestion, and its profile over time