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Pharmacological inhibition of the adenosine A2A receptor can also reverse myeloid-mediated immunosuppression and rescue CD8 T-cell function, sensitizing tumors to similar metastatic castration-resistant prostate cancer to atezolizumab and inducing a favorable ORR [182]
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The constrained oxygenation and nutrient availability in organoid cultures recapitulate the physiological microenvironment of native tissues [69]
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Orthopedics 2013, 36, e575e580
While both can be microsomal, esterases are predominantly located in cytosol
