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Mechanisms Relevant to Dermal Research GHK-Cus documented effects in skin research include stimulation of collagen and glycosaminoglycan synthesis, modulation of matrix metalloproteinases and their inhibitors (TIMP-1 and TIMP-2), promotion of fibroblast migration and survival, and upregulation of VEGF and bFGF secretion by fibroblasts

Acknowledgements This study was supported by Merck Serono S.A.Geneva, Switzerland

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