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Tier 3 interventions are not inherently unsafe or ineffective

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Brain renin-angiotensin: a new look at an old system

Currently, despite autograft is still broadly used as the gold standard clinical treatment option, nerve conduits are certainly considered a promising strategy to assist and support peripheral nerve regeneration, as acting as a guidance for axons growth (Shen et al., 2022)

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The path forward for cortistatin likely requires development of selective analogs with improved pharmacokinetics and a clinically feasible administration route