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Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma

It can take several days to weeks for the treatments appetite-suppressing and lipogenic effects to kick in

In addition, SIRT1 regulates the expression of the antioxidant genes SOD2 (manganese superoxide dismutase), NRF1, and UCP3

Latourte et al

Disabling CBP/p300-binding to NRF2 broadly attenuated NRF2 transcriptional activity resulting in an altered metabolic (depletion of glutathione) and lipidomic (specific depletion of triglycerides) cellular landscape

In different cellular environments, p53 is thought to promote or inhibit ferroptosis (Sheng et al., 2024).This suggests that cuproptosis may induce SAW through the mitochondrial dysfunction mechanisms that have been associated with ferroptosis