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Originator Merck carried it through Phase 2 trials and a Phase 2b hip-fracture study but never filed for approval, so there is no FDA-approved prescription version

Mistake #3: Incorrect Concentration Math Error: Confusing peptide vial amount with desired concentration (e.g., adding 10mL water to a 10mg vial thinking it creates "10mg" solution)

The IGF-1 signaling axis is widely studied for its involvement in cellular proliferation, metabolic regulation, tissue growth, and intracellular signaling mechanisms in preclinical research models

It's even nicknamed as the "Egon Gun" in some of the game files

[DOI] [PubMed] [Google Scholar] 108.Verlaan S., Aspray T.J., Bauer J.M., Cederholm T., Hemsworth J., Hill T.R., McPhee J.S., Piasecki M., Seal C., Sieber C.C., et al

On the question of raw, proven efficacy for photoaging, the honest answer is that tretinoin has the stronger evidence base but the picture is more nuanced than a simple winner-takes-all verdict