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The original paper described the block utilizing landmark techniques and tactile feel during block performance, though the associated risk of pneumothorax was likely responsible for the technique falling out of favor
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This anti-tumor effect may be achieved through mechanisms such as regulating the immune system, inhibiting tumor cell proliferation, and inducing tumor cell apoptosis
We now know some of the compounds responsible for the behaviour, including hypoxanthine-3- N -oxide (Brown et al., Reference Brown, Adrian, Smyth, Leet and Brennan2000
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