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Both in vivo studies in mice and in vitro studies in cultured human aortic endothelial and vascular smooth muscle cells have shown that physiological levels of TMAO induce expression of inflammatory cytokines and adhesion molecules

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These effects are largely attributed to its capacity to stabilize mitochondrial membranes, scavenge free radicals and modulate intracellular signaling pathways involved in cell survival (Sener et al

Diet diurnally regulates small intestinal microbiomeepithelialimmune homeostasis and enteritis
