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Hedges' g effect values of 0.20, 0.50 and 0.80 respectively represent small, medium and large effects ( Meta-analysis was performed using R Studio's Metafor package ( I 2 statistics for quantification and Cochran's Q for statistical significance test to evaluate heterogeneity

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the passage of bacteria or bacterial products such as endotoxin from the gut to the liver through portal bloodstream, these products will activate hepatic Kpffer cells, which can eliminate the enterogenous bacteria and toxins through phagocytosis, and induce severe systemic inflammation through releasing inflammatory mediators

To examine treatment group clustering in the NMDS plots, PERMANOVA tests were conducted using the adonis function in the vegan package

Adeno-associated virus as a delivery vector for gene therapy of human diseases