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doi: 10.1017/S1041610215000046

On the other hand, TB-500 mediated cytoskeletal regulation can influence additional signaling networks because actin dynamics are closely linked to cell adhesion, migration signaling, and intracellular transport pathways [7]

[DOI] [PMC free article] [PubMed] [Google Scholar] [26].Hornig M, Montoya JG, Klimas NG, et al

-Hydroxy--methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats

The timing concern is purely mechanical, related to gastric emptying rate and pH exposure
