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Phagocytosis is suppressed via CD47/SIRP activation

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To assess the effect of CPZ on demyelination, slices were treated for 72 h with either 1 mM CPZ, 1 mM CPZ + cytokines (15 ng/mL Tumour Necrosis Factor-a (TNFa) + 15 ng/mL Interferon-g (IFNg)), 1 mM CPZ + 15 mg/mL LPS, cytokines alone or 15 mg/mL LPS alone

This creates a broad prohibition that captures emerging peptides even before specific detection methods are developed