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Leyane et al., 2022) Specific endogenous proteins and environmental contaminants can induce microglia to become too active and generate ROS, which can be neurotoxic (Afsheen et al., 2022) A growing body of evidence suggests that activation of various enzymes, such as NOX2 in microglia, is neurotoxic not only by producing extracellular ROS that harm nearby neurons but also by commencing redox signaling in microglia that intensifies the pro-inflammatory response (Pajares et al., 2020
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The HFD was formulated by reducing carbohydrate content and increasing fat content, primarily through the addition of lard and soybean oil
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After washing sections in PBS for 10 min, they were exposed to 3% (vol/vol) H 2 O 2 in PBS for 15 min
The sores caused by both forms of the virus are similar in appearance
