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This syndrome is characterized by clinical symptoms of sickness behavior such as leaden paralysis of the limbs, hypersomnia, and hyperphagia/weight gain, while mood reactivity is unimpaired, i.e., mood brightens in response to positive events (according to DSM-5 criteria for MDD with atypical features), while still suffering from lack of concentration and higher levels of exhaustibility as in melancholic MDD [99]

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Kisspeptin, a group of peptide fragments encoded by the KISS1 gene in humans, plays a crucial role in various physiological functions, particularly in the regulation of reproductive hormones and sexual behavior

They used chemical extracts to inhibit bacterial growth in both cultures and in infected mice

When flags for hypertriglyceridaemia are applied, we suggest laboratories consider adding an additional comment to prompt clinicians to exclude secondary causes (a review of which is beyond the scope of this article), and to consider investigation for inherited metabolic diseases/genetic causes of hypertriglyceridaemia