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Moreover, DHM decreased the levels of pyroptosis-related proteins, such as IL-18, NLRP3, ASC, GSDMD, and Caspase-1, and upregulated the levels of oxidative stress-related proteins, such as SOD1 and HO-1, in SCI mice
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As dopamine replacement treatment remains the most effective symptomatic pharmacotherapy for PD, herein we provide an overview of the current pharmacotherapies, summarize the clinical development status of novel dopaminergic agents, and highlight the challenge and opportunity of emerging preclinical dopaminergic approaches aimed at managing the features and progression of PD.
