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If these micro-organisms take hold, they damage the structure of the gut wall and the body struggles to keep out unwanted bacteria and toxins

23 , 24 The synovial space is another site that is greatly affected by ROS in the onset of OA

The central role of p53 in stress-induced apoptosis, the frequent TP53 mutations in tumors, and the high levels of mutant p53 in tumor cells have stimulated efforts to develop novel cancer therapy by reactivating mutant p53 5

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It acts as a coenzyme in various enzymatic reactions and is often promoted for supporting healthy hair, skin, and nails, although scientific evidence for these cosmetic benefits in individuals without biotin deficiency remains limited

Based on predefined inclusion and exclusion criteria, 6,180 apparently healthy individuals were ultimately included, comprising 2,996 males and 3,184 females, aged 20 to 79 years