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Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes

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Tirzepatide discontinuation data tells a similar story

Importantly, the pivotal cardiovascular and obesity outcome trials of GLP-1RAs, including the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN), Semaglutide Treatment Effect in People with obesity (STEP), and SURPASS (tirzepatide) programs, did not report clinically meaningful increases in AITD or sustained thyroid dysfunction [7,8,30]

However, many users transition to a lower, maintenance dose after achieving their primary goal to save money and sustain results