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Clinical applications address COPD support (10 nanomolar concentration in research restored lung fibroblast function), acute injury recovery (reduced inflammatory cell infiltration in lung injury models), and general tissue regeneration (systemic administration improved healing at distant body locations)

and Li T., Pharmacology of Bile Acid Receptors: Evolution of Bile Acids From Simple Detergents to Complex Signaling Molecules, Pharmacological Research 104 (2016): 921

Interestingly, mitochondria are also a major source of reactive oxygen species (ROS) due to electron leakage from the ETC [15, 16]

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The therapy also modulates the synthesis of prostaglandins, impacts bradykinin release [26], and optimizes immune functions, particularly enhancing the activity of macrophages pivotal to immune reactions [3, 17]

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