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Up to 40 studies covering almost 1,500 human subjects have been reported since the 1920s in the literature using intravenous infusions of bilirubin with a relatively good safety profile (for a review of these studies, see [134])

doi: 10.1177/20543581221100023 93 KitamuraH.TanakaS.HiyamutaH.TsuruyaK.KitazonoT.NakanoT

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After binding of metal ions and ATP, GlnA1 converts from a relaxed (inactive) to a taut (active) state [356, 359]