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Extend the required contraception period to 90 days post-final dose to account for spermatogenic cycle duration in males and potential residual tissue concentrations

However, studies assessing bioavailability of B12 from specific food sources in healthy participants have shown that absorption varies depending on both the specific food product and the magnitude of the dose, ranging from 36%24% for egg products (dose 0.30.94mg, respectively), 83%52% for lean meat (dose 0.545.11mg, respectively), 42%30% for fish (dose 2.113.1mg, respectively) and 49%4.5% for liver products (dose 0.538mg, respectively) (Doets et al., 2013)

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The risk is unregulated online sellers, inaccurate dosing, and self-administration without medical oversight