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These stressors disrupt essential physiological and biochemical processes in plants, often causing oxidative damage and compromising metabolic homeostasis (Boyer 1982

[DOI] [PubMed] [Google Scholar] 52.Kratz F, DOXO-EMCH (INNO-206): the first albumin-binding prodrug of doxorubicin to enter clinical trials
This is because they can function as redox catalysts, thereby enhancing the electron transfer of various electroactive biological species (primarily redox proteins) without necessitating the use of electron transfer mediators [52]

Ice crystal formation can damage peptide structures and reduce potency

Recent studies have identified uncoupling protein-2 (UCP2) as a potential therapeutic target in the pathophysiology of atherosclerosis [49]
