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While it has been associated with numerous negative health impacts, the kidney has been noted to be its main target organ and studies indicate its association with nephrotoxicity in humans and animals

chiefly the inferior vesical artery, but also the internal pudendal and middle rectal arteries [8]
10.1023/A:1026568329860 78 LenzH

The formation of urate hydroperoxide, as an intermediate in urate oxidation, is hypothesized to contribute to oxidative damage in diseases like gout and other inflammatory conditions

Its called news suppression
doi: 10.1016/j.intimp.2019.03.021
