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In a study of people with moderate to severe psoriasis, the vitamin D levels of patients with psoriasis were significantly lower than those of people without psoriasis

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These changes have been associated with increased intestinal permeability, elevated systemic endotoxin levels, and immune dysregulation, all of which may contribute to the development and progression of thyroid dysfunction (Miquel et al., 2013

Although VitB12 deficiency is known to be associated with a high oxidative stress status, there is a question about whether the accumulation of HCy due to a deficiency in VitB12 might contribute to oxidative stress buildup in the brain

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