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doi: 10.3748/wjg.v20.i30.10368 113 WangY.-C.HuangK.-M

It is interesting to note that synthetic GHRPs had been discovered before the natural ones, which was part of the socalled reversed pharmacology approach, where synthetic GHSs had helped discover the GH secretagogue receptor and the natural GHS ghrelin was identified and isolated thereafter [2, 3, 4, 5, 6]

This divergence likely reflects distinct conformational requirements for direct substrate turnover versus protein-mediated electron transfer

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