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Ri and R 2 are independently selected from the group consisting of H, linear or branched alkyl (1-25C), aralkyl (6-26C), cycloalkyl (6-25C), heterocycles (6-20C), ethers or polyethers (3-25C), and where Ri-R 2 together have 2-20C atoms and form a macrocycle with the remainder of formula I

Koffler et al

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Recent preclinical and clinical data support the promise of several agents

Multicenter validation of spin-density projection-assisted R2-MRI for the noninvasive measurement of liver iron concentration

Histone modifications influence the regulation of chromatin dynamics in processes such as gene regulation, DNA repair, cell proliferation, and apoptosis